LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA . LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin .
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [PUBMED:16199883]. It may control smooth muscle cell proliferation following artery injury through PDGFA repression and may also bind double-stranded RNA. It interacts with the leucine-rich repeat domain of human flightless-I (FliI) protein [PUBMED:19265123].
Suriano AR, Sanford AN, Kim N, Oh M, Kennedy S, Henderson MJ, Dietzmann K, Sullivan KE;, Mol Cell Biol. 2005;25:9073-9081.: GCF2/LRRFIP1 represses tumor necrosis factor alpha expression. PUBMED:16199883 EPMC:16199883 .
Liu J, Bang AG, Kintner C, Orth AP, Chanda SK, Ding S, Schultz PG;, Proc Natl Acad Sci U S A. 2005;102:1927-1932.: Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. PUBMED:15677333 EPMC:15677333.