EuRBPDB

Microtus_ochrogasterFamily: LUC7 Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Luc7l3
Luc7l2
Luc7l

Introduction

Pfam

This family contains the N terminal region of several LUC7 protein homologues and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein [1] with a role in splice site recognition [2]. The family also contains human and mouse LUC7 like (LUC7L) proteins [3] and human cisplatin resistance-associated overexpressed protein (CROP) [4].

InterPro

This family consists of several Luc7 protein homologues that are restricted to eukaryotes. In budding yeast, Luc7 is an essential subunit of the yeast U1 snRNP, which forms the spliceosomal commitment complex with other proteins that targets pre-mRNA to the splicing pathway [PUBMED:17726058, PUBMED:11170747]. Its N-terminal zinc finger has been found to bind pre-mRNA [PUBMED:17726058]. This entry also contains human and mouse Luc7 like (LUC7L) proteins [PUBMED:10500099].

Reference

  1. Stevens SW, Ryan DE, Ge HY, Moore RE, Young MK, Lee TD, Abelson J; , Mol Cell 2002;9:31-44.: Composition and functional characterization of the yeast spliceosomal penta-snRNP. PUBMED:11804584 EPMC:11804584 .

  2. Fortes P, Bilbao-Cortes D, Fornerod M, Rigaut G, Raymond W, Seraphin B, Mattaj IW; , Genes Dev 1999;13:2425-2438.: Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition. PUBMED:10500099 EPMC:10500099 .

  3. Tufarelli C, Frischauf AM, Hardison R, Flint J, Higgs DR; , Genomics 2001;71:307-314.: Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. PUBMED:11170747 EPMC:11170747 .

  4. Nishii Y, Morishima M, Kakehi Y, Umehara K, Kioka N, Terano Y, Amachi T, Ueda K; , FEBS Lett 2000;465:153-156.: CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line. PUBMED:10631324 EPMC:10631324.