Gorilla_gorillaFamily: MMR_HSR1 Number of Genes: 112
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
ARF4
LSG1
-
NKIRAS2
SEPT8
GUF1
EIF5B
ARL5A
EHD2
GIMAP7
GIMAP4
-
EHD3
ARL3
DNAJC27
ARL11
SEPT2
-
ARFRP1
ARL8B
-
-
MFN2
ARL2
RAB5C
ARL6
RAB7A
RAB39B
MTG2
RAB44
-
-
RABL3
DRG2
-
DNM1L
RASEF
RAB25
-
-
SEPT12
GNL3L
MTIF2
GNL2
KRAS
RAB18
RASL11A
SEPT3
GTPBP8
MFN1
RAB9B
SEPT6
RAB1B
SEPT14
CRACR2A
RAB6A
ARL1
DRG1
ARF1
-
GNL3
RRAGB
EHD4
RASL11B
IRGC
SEPT9
EEF2
GTPBP4
-
-
RAB11A
RAB11B
GNL1
RAB2B
RHEB
SEPT11
GPN1
HRAS
RAB22A
GTPBP3
ERAL1
RAB5A
RAB36
-
RAB34
ARF5
SEPT1
-
RAB30
RRAGA
OLA1
GIMAP2
RAB33A
ARL4C
-
-
-
RAB13
SAR1A
GIMAP8
RAB1A
RAB9A
RAB14
ARL8A
SRPRB
RAB6B
GTPBP10
ARL14
-
-
-
-
-
-
ARF3
RAB33B
NOA1
ARL4D
RAB2A
NRAS
ARL4A

Introduction

Pfam

The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.

InterPro

Several proteins have recently been shown to contain the 5 structural motifs characteristic of GTP-binding proteins [PUBMED:1449490]. These include murine DRG protein; GTP1 protein from Schizosaccharomyces pombe; OBG protein from Bacillus subtilis [PUBMED:12429099]; ferrous iron transport protein B [PUBMED:20123128] and several others.

Reference

  1. Vernet C, Ribouchon MT, Chimini GPontarotti P; , Mamm Genome 1994;5:100-105.: Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. PUBMED:8180467 EPMC:8180467 .

  2. Bassler J, Kallas M, Hurt E;, J Biol Chem. 2006;281:24737-24744.: The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles. PUBMED:16803892 EPMC:16803892 .

  3. Jain N, Dhimole N, Khan AR, De D, Tomar SK, Sajish M, Dutta D, Parrack P, Prakash B;, Biochem Biophys Res Commun. 2009;379:201-205.: E. coli HflX interacts with 50S ribosomal subunits in presence of nucleotides. PUBMED:19109926 EPMC:19109926 .

  4. Dutta D, Bandyopadhyay K, Datta AB, Sardesai AA, Parrack P;, J Bacteriol. 2009;191:2307-2314.: Properties of HflX, an enigmatic protein from Escherichia coli. PUBMED:19181811 EPMC:19181811 .

  5. Shields MJ, Fischer JJ, Wieden HJ;, Biochemistry. 2009;48:10793-10802.: Toward understanding the function of the universally conserved GTPase HflX from Escherichia coli: a kinetic approach. PUBMED:19824612 EPMC:19824612.