EuRBPDB

Drosophila_melanogasterFamily: MT-A70 Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
CG14906
Mettl14
Ime4

Introduction

Pfam

MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA:m6A methyl-transferase (MTase), an enzyme that sequence-specifically methylates adenines in pre-mRNAs.

InterPro

N6-methyladenosine (m6A) is present at internal sites in some mRNAs. m6A affects different aspects of mRNA metabolism, such as half-life, splicing, and translation [PUBMED:24284625, PUBMED:26751643, PUBMED:26593424, PUBMED:26046440, PUBMED:25799998].

Reference

  1. Bujnicki JM, Feder M, Radlinska M, Blumenthal RM; , J Mol Evol 2002;55:431-444.: Structure Prediction and Phylogenetic Analysis of a Functionally Diverse Family of Proteins Homologous to the MT-A70 Subunit of the Human mRNA:m6A Methyltransferase. PUBMED:12355263 EPMC:12355263.