EuRBPDB

Drosophila_melanogasterFamily: Mago_nashi Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
mago

Introduction

Pfam

This family was originally identified in Drosophila and called mago nashi, it is a strict maternal effect, grandchildless-like, gene [3]. The human homologue has been shown to interact with an RNA binding protein Q9Y5S9 [1]. An RNAi knockout of the C. elegans homologue causes masculinization of the germ line (Mog phenotype) hermaphrodites, suggesting it is involved in hermaphrodite germ-line sex determination [2]. Mago nashi has been found to be part of the exon-exon junction complex that binds 20 nucleotides upstream of exon-exon junctions [4].

InterPro

This family was originally identified in Drosophila and called mago nashi, it is a strict maternal effect, grandchildless-like, gene [PUBMED:1765008]. The protein is an integral member of the exon junction complex (EJC). The EJC is a multiprotein complex that is deposited on spliced mRNAs after intron removal at a conserved position upstream of the exon-exon junction, and transported to the cytoplasm where it has been shown to influence translation, surveillance, and localization of the spliced mRNA. It consists of four core proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP and is supposed to be a binding platform for more peripherally and transiently associated factors along mRNA travel. Mago and Y14 form a stable heterodimer that stabilizes the complex by inhibiting eIF4AIII's ATPase activity. Mago-Y14 heterodimer has been shown to interact with the cytoplasmic protein PYM, an EJC disassembly factor, and specifically binds to the karyopherin nuclear receptor importin 13 [PUBMED:18164611, PUBMED:20818392, PUBMED:20946982, PUBMED:15734573, PUBMED:12781131, PUBMED:15145352, PUBMED:18423193, PUBMED:1765008, PUBMED:10656761, PUBMED:10662555, PUBMED:11707413, PUBMED:9272960, PUBMED:12730685, PUBMED:14968132, PUBMED:15567724, PUBMED:16380844, PUBMED:17545126].

Reference

  1. Zhao XF, Nowak NJ, Shows TB, Aplan PD; , Genomics 2000;63:145-148.: MAGOH interacts with a novel RNA-binding protein. PUBMED:10662555 EPMC:10662555 .

  2. Li W, Boswell R, Wood WB; , Dev Biol 2000;218:172-182.: mag-1, a homolog of Drosophila mago nashi, regulates hermaphrodite germ-line sex determination in Caenorhabditis elegans. PUBMED:10656761 EPMC:10656761 .

  3. Boswell RE, Prout ME, Steichen JC; , Development 1991;113:373-384.: Mutations in a newly identified Drosophila melanogaster gene, mago nashi, disrupt germ cell formation and result in the formation of mirror-image symmetrical double abdomen embryos. PUBMED:1765008 EPMC:1765008 .

  4. Kataoka N, Diem MD, Kim VN, Yong J, Dreyfuss G; , EMBO J 2001;20:6424-6433.: Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. PUBMED:11707413 EPMC:11707413.