EuRBPDB

Cercocebus_atysFamily: Methyltr_RsmB-F Number of Genes: 8

Ensembl ID	Symbol	Entrez ID
ENSCATG00000006182	NOP2	105583022
ENSCATG00000015253	NSUN5	105593368
ENSCATG00000032928	NSUN3	105583571
ENSCATG00000037551	NSUN4	105594569
ENSCATG00000038294	NSUN6	105583821
ENSCATG00000042165	-	-
ENSCATG00000043174	NSUN7	105584823
ENSCATG00000045020	-	105585975

Introduction

Pfam

This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme [1,2]. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2 with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA [1,2].

InterPro

The C-terminal catalytic domain of ribosomal RNA cysteine methyltransferases is highly conserved in archaeal, bacterial and eukaryotic proteins [PUBMED:21123870], such as ribosomal RNA methyltransferase B (RsmB, Sun, Fmu) and Nop2. Escherichia coli RsmB methylates cysteine C967 in 16S rRNA [PUBMED:21123870]. Nop2 methylates cysteine C2870 in the 25S rRNA of S. cerevisiae [PUBMED:23913415] and is critical for 60S biogenesis [PUBMED:8972218].

Reference

Ishikawa I, Sakai N, Tamura T, Yao M, Watanabe N, Tanaka I;, Proteins. 2004;54:814-816.: Crystal structure of human p120 homologue protein PH1374 from Pyrococcus horikoshii. PUBMED:14997580 EPMC:14997580 .
Demirci H, Larsen LH, Hansen T, Rasmussen A, Cadambi A, Gregory ST, Kirpekar F, Jogl G;, RNA. 2010;16:1584-1596.: Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. PUBMED:20558545 EPMC:20558545.