This family includes proteins related to Mpp10 (M phase phosphoprotein 10). The U3 small nucleolar ribonucleoprotein (snoRNP) is required for three cleavage events that generate the mature 18S rRNA from the pre-rRNA. In Saccharomyces cerevisiae, depletion of Mpp10, a U3 snoRNP-specific protein, halts 18S rRNA production and impairs cleavage at the three U3 snoRNP-dependent sites .
Mpp10 (M phase phosphoprotein 10) is a component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) required for three cleavage events that generate the mature 18S rRNA from the pre-rRNA [PUBMED:9391061, PUBMED:9450966].
Westendorf JM, Konstantinov KN, Wormsley S, Shu MD, Matsumoto-Taniura N, Pirollet F, Klier FG, Gerace L, Baserga SJ; , Mol Biol Cell 1998;9:437-449.: M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component. PUBMED:9450966 EPMC:9450966 .
Dragon F, Gallagher JE, Compagnone-Post PA, Mitchell BM, Porwancher KA, Wehner KA, Wormsley S, Settlage RE, Shabanowitz J, Osheim Y, Beyer AL, Hunt DF, Baserga SJ; , Nature 2002;0:0-0.: A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. PUBMED:12068309 EPMC:12068309 .
Lee SJ, Baserga SJ; , Proc Natl Acad Sci U S A 1997;94:13536-13541.: Functional separation of pre-rRNA processing steps revealed by truncation of the U3 small nucleolar ribonucleoprotein component, Mpp10. PUBMED:9391061 EPMC:9391061.