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NCBP3 and NCBP1 form an alternative cap-binding complex in higher eukaryotes. NCBP3 binds mRNA, associates with components of the mRNA processing machinery and contributes to polyA RNA export .
The cap-binding complex (CBC) consisting of NCBP2 and its adaptor NCBP1 is believed to bind all capped RNA and to be necessary for its processing and intracellular localisation. Nuclear cap-binding protein subunit 3 (NCBP3), together with NCBP1, forms an alternative CBC in higher eukaryotes. NCBP3 binds mRNA, associates with components of the mRNA processing machinery and contributes to poly(A) RNA export [PUBMED:26382858].
Gebhardt A, Habjan M, Benda C, Meiler A, Haas DA, Hein MY, Mann A, Mann M, Habermann B, Pichlmair A;, Nat Commun. 2015;6:8192.: mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. PUBMED:26382858 EPMC:26382858.