EuRBPDB

Haplochromis_burtoniFamily: NTF2 Number of Genes: 6

Ensembl ID	Symbol	Entrez ID
ENSHBUG00000002401	-	102303702
ENSHBUG00000002974	nxt2	102306552
ENSHBUG00000007387	g3bp2	102308936
ENSHBUG00000010303	nutf2	102300131
ENSHBUG00000011664	g3bp1	102291207
ENSHBUG00000012886	zgc:153681	102288914

Introduction

Pfam

This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.

InterPro

Nuclear transport factor 2 (NTF2) is a homodimer which stimulates efficient nuclear import of a cargo protein. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins. NTF2 folds into a cone with a deep hydrophobic cavity, the opening of which is surrounded by several negatively charged residues. RanGDP binds to NTF2 by inserting a conserved phenylalanine residue into the hydrophobic pocket of NTF2 and making electrostatic interactions with the conserved negatively charged residues that surround the cavity [PUBMED:9533885].

Reference

Stewart M, Kent HM, McCoy AJ; , J Mol Biol 1998;277:635-646.: Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran. PUBMED:9533885 EPMC:9533885.