EuRBPDB

Microtus_ochrogasterFamily: NTF2 Number of Genes: 8

Ensembl ID	Symbol	Entrez ID
ENSMOCG00000000939	Nxf1	101998970
ENSMOCG00000005709	G3bp1	102000318
ENSMOCG00000007176	Nxt2	-
ENSMOCG00000010046	Nxf3	101994662
ENSMOCG00000016364	Nxf2	101994989
ENSMOCG00000018712	Nxt1	101981593
ENSMOCG00000019909	-	102002051
ENSMOCG00000020007	G3bp2	101980461

Introduction

Pfam

This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.

InterPro

Nuclear transport factor 2 (NTF2) is a homodimer which stimulates efficient nuclear import of a cargo protein. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins. NTF2 folds into a cone with a deep hydrophobic cavity, the opening of which is surrounded by several negatively charged residues. RanGDP binds to NTF2 by inserting a conserved phenylalanine residue into the hydrophobic pocket of NTF2 and making electrostatic interactions with the conserved negatively charged residues that surround the cavity [PUBMED:9533885].

Reference

Stewart M, Kent HM, McCoy AJ; , J Mol Biol 1998;277:635-646.: Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran. PUBMED:9533885 EPMC:9533885.