Proteins in this family have been implicated in the assembly of the large subunit of the ribosome  and in telomere maintenance . Some proteins in this family contain a CCCH zinc finger. This family contains a protein called human fragile X mental retardation-interacting protein 1, which is known to bind RNA  and is phosphorylated upon DNA damage .
Nuclear fragile X mental retardation-interacting protein 1 (Nufip1) has been implicated in the assembly of the large subunit of the ribosome [PUBMED:10567587] and in telomere maintenance [PUBMED:16552446]. It is known to bind RNA [PUBMED:10556305] and is phosphorylated upon DNA damage [PUBMED:17525332]. This entry represents a conserved domain found within Nufip1. Some proteins containing this region also contain a CCCH zinc finger.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ; , Science. 2007;316:1160-1166.: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PUBMED:17525332 EPMC:17525332 .
Kressler D, Doere M, Rojo M, Linder P; , Mol Cell Biol. 1999;19:8633-8645.: Synthetic lethality with conditional dbp6 alleles identifies rsa1p, a nucleoplasmic protein involved in the assembly of 60S ribosomal subunits. PUBMED:10567587 EPMC:10567587 .
Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A; , PLoS Genet. 2006;2:e35.: Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PUBMED:16552446 EPMC:16552446 .
Bardoni B, Schenck A, Mandel JL; , Hum Mol Genet. 1999;8:2557-2566.: A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. PUBMED:10556305 EPMC:10556305.