Gambusia_affinisFamily: NUFIP1 Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
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Introduction

Pfam

Proteins in this family have been implicated in the assembly of the large subunit of the ribosome [2] and in telomere maintenance [3]. Some proteins in this family contain a CCCH zinc finger. This family contains a protein called human fragile X mental retardation-interacting protein 1, which is known to bind RNA [4] and is phosphorylated upon DNA damage [1].

InterPro

Nuclear fragile X mental retardation-interacting protein 1 (Nufip1) has been implicated in the assembly of the large subunit of the ribosome [PUBMED:10567587] and in telomere maintenance [PUBMED:16552446]. It is known to bind RNA [PUBMED:10556305] and is phosphorylated upon DNA damage [PUBMED:17525332]. This entry represents a conserved domain found within Nufip1. Some proteins containing this region also contain a CCCH zinc finger.

Reference

  1. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ; , Science. 2007;316:1160-1166.: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PUBMED:17525332 EPMC:17525332 .

  2. Kressler D, Doere M, Rojo M, Linder P; , Mol Cell Biol. 1999;19:8633-8645.: Synthetic lethality with conditional dbp6 alleles identifies rsa1p, a nucleoplasmic protein involved in the assembly of 60S ribosomal subunits. PUBMED:10567587 EPMC:10567587 .

  3. Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A; , PLoS Genet. 2006;2:e35.: Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PUBMED:16552446 EPMC:16552446 .

  4. Bardoni B, Schenck A, Mandel JL; , Hum Mol Genet. 1999;8:2557-2566.: A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. PUBMED:10556305 EPMC:10556305.