EuRBPDB

Rhinopithecus_roxellanaFamily: Nop Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
NOP56
NOP58
PRPF31

Introduction

Pfam

This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) Q12499 from yeast is the protein component of a ribonucleoprotein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex [1]. Nop56p O00567 and Nop5p interact with Nop1p and are required for ribosome biogenesis [2]. Prp31p p49704 is required for pre-mRNA splicing in S. cerevisiae [3]. Fibrillarin, or Nop, is the catalytic subunit responsible for the methyl transfer reaction of the site-specific 2'-O-methylation of ribosomal and spliceosomal RNA [4].

InterPro

The Nop domain is present in various pre-RNA processing ribonucleoproteins (RNP):

Reference

  1. Wu P, Brockenbrough JS, Metcalfe AC, Chen S, Aris JP; , J Biol Chem 1998;273:16453-16463.: Nop5p is a small nucleolar ribonucleoprotein component required for pre- 18 S rRNA processing in yeast. PUBMED:9632712 EPMC:9632712 .

  2. Gautier T, Berges T, Tollervey D, Hurt E; , Mol Cell Biol 1997;17:7088-7098.: Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. PUBMED:9372940 EPMC:9372940 .

  3. Weidenhammer EM, Singh M, Ruiz-Noriega M, Woolford JL Jr; , Nucleic Acids Res. 1996;24:1164-1170.: The PRP31 gene encodes a novel protein required for pre-mRNA splicing in Saccharomyces cerevisiae. PUBMED:8604353 EPMC:8604353 .

  4. Xue S, Wang R, Yang F, Terns RM, Terns MP, Zhang X, Maxwell ES, Li H;, Mol Cell. 2010;39:939-949.: Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. PUBMED:20864039 EPMC:20864039.