Members of this family of proteins are part of the yeast nuclear pore complex-associated pre-60S ribosomal subunit . The family functions as a highly conserved exonuclease that is required for the 5'-end maturation of 5.8S and 25S rRNAs, demonstrating that 5'-end processing also has a redundant pathway. Nop25 binds late pre-60S ribosomes, accompanying them from the nucleolus to the nuclear periphery; and there is evidence for both physical and functional links between late 60S subunit processing and export .
Nop12 is a novel nucleolar protein required for pre-large subunit rRNA processing and in yeast normal rates of cell growth at low temperatures [PUBMED:11452019].
Suzuki S, Kanno M, Fujiwara T, Sugiyama H, Yokoyama A, Takahashi H, Tanaka J; , Exp Cell Res. 2006;312:1031-1041.: Molecular cloning and characterization of Nop25, a novel nucleolar RNA binding protein, highly conserved in vertebrate species. PUBMED:16430885 EPMC:16430885 .
Oeffinger M, Zenklusen D, Ferguson A, Wei KE, El Hage A, Tollervey D, Chait BT, Singer RH, Rout MP;, Mol Cell. 2009;36:768-781.: Rrp17p is a eukaryotic exonuclease required for 5' end processing of Pre-60S ribosomal RNA. PUBMED:20005841 EPMC:20005841.