EuRBPDB

Oryzias_latipes_hniFamily: PRP38 Number of Genes: 2

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
ENSORLG00020002130	prpf38a	-
ENSORLG00020016276	-	-

Introduction

Pfam

Members of this family are related to the pre mRNA splicing factor PRP38 from yeast [1]. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation [2].

InterPro

Members of this family are related to the pre mRNA splicing factor PRP38 from yeast [PUBMED:1508195], therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation [PUBMED:9582287].

Reference

Blanton S, Srinivasan A, Rymond BC; , Mol Cell Biol 1992;12:3939-3947.: PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels. PUBMED:1508195 EPMC:1508195 .
Xie J, Beickman K, Otte E, Rymond BC; , EMBO J 1998;17:2938-2946.: Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociation. PUBMED:9582287 EPMC:9582287.