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This family represents the N-terminal region of Pescadillo. Pescadillo protein localises to distinct substructures of the interphase nucleus including nucleoli, the site of ribosome biogenesis. During mitosis pescadillo closely associates with the periphery of metaphase chromosomes and by late anaphase is associated with nucleolus-derived foci and prenucleolar bodies. Blastomeres in mouse embryos lacking pescadillo arrest at morula stages of development, the nucleoli fail to differentiate and accumulation of ribosomes is inhibited. It has been proposed that in mammalian cells pescadillo is essential for ribosome biogenesis and nucleologenesis and that disruption to its function results in cell cycle arrest . This family is often found in conjunction with a PF00533 domain.
Pescadillo (PES) protein was first identified as an essential protein for zebrafish embryonic development [PUBMED:8985183]. It is conserved from yeasts to humans. Pescadillo homologues are involved in embryonic development and ribosome biogenesis [PUBMED:19075239, PUBMED:17727835]. It has been linked to chromosomal instability and cancer [PUBMED:15467761, PUBMED:22860098].
Lerch-Gaggl A, Haque J, Li J, Ning G, Traktman P, Duncan SA; , J Biol Chem 2002;277:45347-45355.: Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation. PUBMED:12237316 EPMC:12237316.