This family consists of several mammalian proSAAS precursor proteins. ProSAAS mRNA is expressed primarily in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas); within brain, the mRNA is broadly distributed among neurons. ProSAAS is thought to be an endogenous inhibitor of prohormone convertase 1  may function as a neuropeptide . N-terminal fragments of proSAAS in intracellular Pick Bodies (PBs) may cause a functional disturbance of neurons in Pick's disease .
Prohormone convertases (PCs) 1 and 2 are a family of eukaryotic subtilisins thought to mediate the proteolytic cleavage of many peptide precursors [PUBMED:10409610].
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Kikuchi K, Arawaka S, Koyama S, Kimura H, Ren CH, Wada M, Kawanami T, Kurita K, Daimon M, Kawakatsu S, Kadoya T, Goto K, Kato T; , Biochem Biophys Res Commun 2003;308:646-654.: An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease. PUBMED:12914799 EPMC:12914799.