Microcebus_murinusFamily: ProSAAS Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
PCSK1N

Introduction

Pfam

This family consists of several mammalian proSAAS precursor proteins. ProSAAS mRNA is expressed primarily in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas); within brain, the mRNA is broadly distributed among neurons. ProSAAS is thought to be an endogenous inhibitor of prohormone convertase 1 [1] may function as a neuropeptide [2]. N-terminal fragments of proSAAS in intracellular Pick Bodies (PBs) may cause a functional disturbance of neurons in Pick's disease [3].

InterPro

Prohormone convertases (PCs) 1 and 2 are a family of eukaryotic subtilisins thought to mediate the proteolytic cleavage of many peptide precursors [PUBMED:10409610].

Reference

  1. Fricker LD, McKinzie AA, Sun J, Curran E, Qian Y, Yan L, Patterson SD, Courchesne PL, Richards B, Levin N, Mzhavia N, Devi LA, Douglass J; , J Neurosci 2000;20:639-648.: Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. PUBMED:10632593 EPMC:10632593 .

  2. Mzhavia N, Qian Y, Feng Y, Che FY, Devi LA, Fricker LD; , Biochem J 2002;361:67-76.: Processing of proSAAS in neuroendocrine cell lines. PUBMED:11742530 EPMC:11742530 .

  3. Kikuchi K, Arawaka S, Koyama S, Kimura H, Ren CH, Wada M, Kawanami T, Kurita K, Daimon M, Kawakatsu S, Kadoya T, Goto K, Kato T; , Biochem Biophys Res Commun 2003;308:646-654.: An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease. PUBMED:12914799 EPMC:12914799.