Mus_musculusFamily: ProSAAS Number of Genes: 1
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This family consists of several mammalian proSAAS precursor proteins. ProSAAS mRNA is expressed primarily in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas); within brain, the mRNA is broadly distributed among neurons. ProSAAS is thought to be an endogenous inhibitor of prohormone convertase 1 [1] may function as a neuropeptide [2]. N-terminal fragments of proSAAS in intracellular Pick Bodies (PBs) may cause a functional disturbance of neurons in Pick's disease [3].


Prohormone convertases (PCs) 1 and 2 are a family of eukaryotic subtilisins thought to mediate the proteolytic cleavage of many peptide precursors [PUBMED:10409610].


  1. Fricker LD, McKinzie AA, Sun J, Curran E, Qian Y, Yan L, Patterson SD, Courchesne PL, Richards B, Levin N, Mzhavia N, Devi LA, Douglass J; , J Neurosci 2000;20:639-648.: Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. PUBMED:10632593 EPMC:10632593 .

  2. Mzhavia N, Qian Y, Feng Y, Che FY, Devi LA, Fricker LD; , Biochem J 2002;361:67-76.: Processing of proSAAS in neuroendocrine cell lines. PUBMED:11742530 EPMC:11742530 .

  3. Kikuchi K, Arawaka S, Koyama S, Kimura H, Ren CH, Wada M, Kawanami T, Kurita K, Daimon M, Kawakatsu S, Kadoya T, Goto K, Kato T; , Biochem Biophys Res Commun 2003;308:646-654.: An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease. PUBMED:12914799 EPMC:12914799.