Drosophila_melanogasterFamily: PurA Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



This family represents most of the length of the protein.


The purine-rich element binding (Pur) protein family protein consists PURalpha/beta/gamma in humans. Pur-alpha is a highly conserved, sequence-specific DNA- and RNA-binding protein involved in diverse cellular and viral functions including transcription, replication, and cell growth. Pur-alpha has a modular structure with alternating three basic aromatic class I and two acidic leucine-rich class II repeats in the central region of the protein [PUBMED:1448097].


  1. Chepenik LG, Tretiakova AP, Krachmarov CP, Johnson EM, Khalili K; , Gene 1998;210:37-44.: The single-stranded DNA binding protein, Pur-alpha, binds HIV-1 TAR RNA and activates HIV-1 transcription. PUBMED:9524214 EPMC:9524214.