EuRBPDB

Mus_musculus_c3hhejFamily: RMMBL Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Cpsf3
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Cpsf2
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Cpsf3l
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Introduction

Pfam

The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in PF00753 and are common to all metallo-beta-lactamases. This, the fifth motif [1] appears to be specific to Zn-dependent metallohydrolases such as ribonuclease J 2 [4] which are involved in the processing of mRNA [2,3]. This domain adds essential structural elements to the CASP-domain and is unique to RNA/DNA-processing nucleases, showing that they are pre-mRNA 3a2-end-processing endonucleases [2,3,4].

InterPro

The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in INTERPRO and are common to all metallo-beta-lactamases. This, the fifth motif [PUBMED:12177301], appears to be specific to Zn-dependent metallohydrolases such as ribonuclease J 2 [PUBMED:21764917] which are involved in the processing of mRNA [PUBMED:17128255, PUBMED:20544974]. This domain adds essential structural elements to the CASP-domain and is unique to RNA/DNA-processing nucleases, showing that they are pre-mRNA 3'-end-processing endonucleases [PUBMED:17128255, PUBMED:20544974, PUBMED:21764917].

Reference

  1. Callebaut I, Moshous D, Mornon JP, de Villartay JP; , Nucleic Acids Res 2002;30:3592-3601.: Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family. PUBMED:12177301 EPMC:12177301 .

  2. Mandel CR, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley JL, Tong L; , Nature. 2006;444:953-956.: Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. PUBMED:17128255 EPMC:17128255 .

  3. Nishida Y, Ishikawa H, Baba S, Nakagawa N, Kuramitsu S, Masui R;, Proteins. 2010;78:2395-2398.: Crystal structure of an archaeal cleavage and polyadenylation specificity factor subunit from Pyrococcus horikoshii. PUBMED:20544974 EPMC:20544974 .

  4. Roux CM, DeMuth JP, Dunman PM;, J Bacteriol. 2011;193:5520-5526.: Characterization of components of the Staphylococcus aureus mRNA degradosome holoenzyme-like complex. PUBMED:21764917 EPMC:21764917.