EuRBPDB

Mus_musculus_dba2jFamily: RNA_pol_Rpb2_1 Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Polr3b
-
Polr1b
-
Polr2b
-

Introduction

Pfam

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain [1]. The other lobe (PF04561) is nested within this domain.

InterPro

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain [PUBMED:3116266]. The other lobe, RNA polymerase Rpb2, domain 2, is nested within this domain.

Reference

  1. Falkenburg D, Dworniczak B, Faust DM, Bautz EK; , J Mol Biol 1987;195:929-937.: RNA polymerase II of Drosophila. Relation of its 140,000 Mr subunit to the beta subunit of Escherichia coli RNA polymerase. PUBMED:3116266 EPMC:3116266 .

  2. Cramer P, Bushnell DA, Kornberg RD; , Science 2001;292:1863-1876.: Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. PUBMED:11313498 EPMC:11313498.