EuRBPDB

Microtus_ochrogasterFamily: RNA_pol_Rpb4 Number of Genes: 2
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Crcp
Polr2d

Introduction

Pfam

This family includes the Rpb4 protein. This family also includes C17 (aka CGRP-RCP) is an essential subunit of RNA polymerase III. C17 forms a subcomplex with C25 [5] which is likely to be the counterpart of subcomplex Rpb4/7 in Pol II [4].

InterPro

This entry includes RNA polymerase II subunit RPB4 and its paralogue, RPC9 (also known as Rpc17 in budding yeasts), a subunit of RNA polymerase III [PUBMED:12391170]. The Rpb4 and Rpb7 subunits of yeast RNA polymerase II form a heterodimeric complex essential for promoter-directed transcription initiation. The Rpb4-Rpb7 complex is not required for stable recruitment of polymerase to active preinitiation complexes, suggesting that Rpb4-Rpb7 mediates an essential step subsequent to promoter binding [PUBMED:11087726]. RPC9 may be involved in the recruitment of pol III by the preinitiation complex [PUBMED:11433012, PUBMED:10611227].

Reference

  1. Todone F, Brick P, Werner F, Weinzierl RO, Onesti S; , Mol Cell 2001;8:1137-1143.: Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex. PUBMED:11741548 EPMC:11741548 .

  2. Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C; , Mol Cell Biol. 2003;23:195-205.: An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. PUBMED:12482973 EPMC:12482973 .

  3. Sadhale PP, Woychik NA; , Mol Cell Biol. 1994;14:6164-6170.: C25, an essential RNA polymerase III subunit related to the RNA polymerase II subunit RPB7. PUBMED:8065349 EPMC:8065349 .

  4. Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C; , Mol Cell Biol. 2003;23:195-205.: An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. PUBMED:12482973 EPMC:12482973 .

  5. Jasiak AJ, Armache KJ, Martens B, Jansen RP, Cramer P; , Mol Cell. 2006;23:71-81.: Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model. PUBMED:16818233 EPMC:16818233.