EuRBPDB

Mus_musculus_c3hhejFamily: RNase_Zc3h12a Number of Genes: 7

Ensembl ID	Symbol	Entrez ID
MGP_C3HHeJ_G0016762	Zc3h12d	-
MGP_C3HHeJ_G0021117	Nynrin	-
MGP_C3HHeJ_G0021119	Khnyn	-
MGP_C3HHeJ_G0028461	Zc3h12a	-
MGP_C3HHeJ_G0033597	N4bp1	-
MGP_C3HHeJ_G0034488	Zc3h12c	-
MGP_C3HHeJ_G0035598	Zc3h12b	-

Introduction

Pfam

This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes [1]. It has been suggested that this domain belongs to the PIN domain superfamily [1]. This domain has also been identified as part of the NYN domain family [2].

InterPro

This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes [PUBMED:19322177]. It has been suggested that this domain belongs to the PIN domain superfamily [PUBMED:19322177]. This domain has also been identified as part of the NYN domain family [PUBMED:17114934].

Reference

Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T, Satoh T, Kato H, Tsujimura T, Nakamura H, Akira S;, Nature;458:1185-1190.: Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. PUBMED:19322177 EPMC:19322177 .
Anantharaman V, Aravind L; , RNA Biol. 2006; [Epub ahead of print]: The NYN Domains: Novel Predicted RNAses with a PIN Domain-Like Fold. PUBMED:17114934 EPMC:17114934.