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No Pfam abstract.
Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [PUBMED:11297922, PUBMED:11290319]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits.
Markus MA, Hinck AP, Huang S, Draper DE, Torchia DA; , Nat Struct Biol 1997;4:70-77.: High resolution solution structure of ribosomal protein L11-C76, a helical protein with a flexible loop that becomes structured upon binding to RNA. PUBMED:8989327 EPMC:8989327 .
Hinck AP, Markus MA, Huang S, Grzesiek S, Kustonovich I, Draper DE; , J Mol Biol 1997;274:101-113.: The RNA binding domain of ribosomal protein L11: Three- dimensional structure of the RNA-bound form of the protein and its interaction with 23S rRNA. PUBMED:9398519 EPMC:9398519.