Mus_musculus_c3hhejFamily: Ribosomal_L40e Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Gm5239
-
Uba52
-
Kxd1
-

Introduction

Pfam

Bovine L40 has been identified as a secondary RNA binding protein [1]. L40 is fused to a ubiquitin protein [2].

InterPro

Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [PUBMED:11297922, PUBMED:11290319]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits.

Reference

  1. Piatyszek MA, Denslow ND, O'Brien TW; , Nucleic Acids Res 1988;16:2565-2583.: RNA binding proteins of the large subunit of bovine mitochondrial ribosomes. PUBMED:3129699 EPMC:3129699 .

  2. Chan YL, Suzuki K, Wool IG; , Biochem Biophys Res Commun 1995;215:682-690.: The carboxyl extensions of two rat ubiquitin fusion proteins are ribosomal proteins S27a and L40. PUBMED:7488009 EPMC:7488009.