Mus_musculusFamily: RtcB Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



This family of RNA ligases ( EC: join 2',3'-cyclic phosphate and 5'-OH ends. They catalyse the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage [1-3].


RctB is a RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. It probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester [PUBMED:21224389].


  1. Tanaka N, Meineke B, Shuman S;, J Biol Chem. 2011;286:30253-30257.: RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo. PUBMED:21757685 EPMC:21757685 .

  2. Tanaka N, Shuman S;, J Biol Chem. 2011;286:7727-7731.: RtcB is the RNA ligase component of an Escherichia coli RNA repair operon. PUBMED:21224389 EPMC:21224389 .

  3. Popow J, Englert M, Weitzer S, Schleiffer A, Mierzwa B, Mechtler K, Trowitzsch S, Will CL, Luhrmann R, Soll D, Martinez J;, Science. 2011;331:760-764.: HSPC117 is the essential subunit of a human tRNA splicing ligase complex. PUBMED:21311021 EPMC:21311021.