EuRBPDB

Mus_musculus_dba2jFamily: SAP Number of Genes: 16

Ensembl ID	Symbol	Entrez ID
MGP_DBA2J_G0016696	Hnrnpu	-
MGP_DBA2J_G0017143	Ccar1	-
MGP_DBA2J_G0017724	Sarnp	-
MGP_DBA2J_G0018312	Myocd	-
MGP_DBA2J_G0021152	Acin1	-
MGP_DBA2J_G0021939	Mkl1	-
MGP_DBA2J_G0021960	Xrcc6	-
MGP_DBA2J_G0022363	Mkl2	-
MGP_DBA2J_G0023755	Safb2	-
MGP_DBA2J_G0023756	-	-
MGP_DBA2J_G0024647	Hnrnpul2	-
MGP_DBA2J_G0030928	Rad18	-
MGP_DBA2J_G0031702	Hnrnpul1	-
MGP_DBA2J_G0032065	Mamstr	-
MGP_DBA2J_G0033357	Eri1	-
MGP_DBA2J_G0034815	Sltm	-

Introduction

Pfam

The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.

InterPro

The SAP motif is a 35-residue motif, which has been named after SAF-A/B, Acinus and PIAS, three proteins known to contain it. The SAP motif is found in a variety of nuclear proteins involved in transcription, DNA repair, RNA processing or apoptotic chromatin degradation. As the sap motif of SAF-A has been shown to be essential for specific DNA binding activity, it has been proposed that it could be a DNA-binding motif [PUBMED:10694879].

Reference

Aravind L, Koonin EV; , Trends Biochem Sci 2000;25:112-114.: SAP - a putative DNA-binding motif involved in chromosomal organization. PUBMED:10694879 EPMC:10694879 .
Iida T, Kawaguchi R, Nakayama J; , Curr Biol. 2006;16:1459-1464.: Conserved ribonuclease, Eri1, negatively regulates heterochromatin assembly in fission yeast. PUBMED:16797182 EPMC:16797182.