EuRBPDB

Microtus_ochrogasterFamily: SART-1 Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Sart1

Introduction

Pfam

SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing [1]. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae [3]. SART-1 is a known tumour antigen in a range of cancers recognised by T cells [1].

InterPro

This entry represents U4/U6.U5 tri-snRNP-associated proteins, including SART1 from animals, Snu66 from yeasts and DOT2 from Arabidopsis.

Reference

  1. Wilkinson CR, Dittmar GA, Ohi MD, Uetz P, Jones N, Finley D; , Curr Biol 2004;14:2283-2288.: Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast. PUBMED:15620657 EPMC:15620657 .

  2. Wilkinson CR, Dittmar GA, Ohi MD, Uetz P, Jones N, Finley D; , Curr Biol 2004;14:2283-2288.: Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast. PUBMED:15620657 EPMC:15620657 .

  3. Makarov EM, Makarova OV, Urlaub H, Gentzel M, Will CL, Wilm M, Luhrmann R; , Science 2002;298:2205-2208.: Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. PUBMED:12411573 EPMC:12411573.