EuRBPDB

Mus_musculus_c3hhejFamily: SID-1_RNA_chan Number of Genes: 2

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
MGP_C3HHeJ_G0022567	Sidt1	-
MGP_C3HHeJ_G0034428	Sidt2	-

Introduction

Pfam

This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps [1]. They are required for systemic RNA interference [2,3]. This family of proteins belong to the CREST superfamily [4] which are distantly related to GPCRs.

InterPro

This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps [PUBMED:12970568]. They are required for systemic RNA interference [PUBMED:11834782,PUBMED:16202143, PUBMED:23396108].

Reference

Feinberg EH, Hunter CP;, Science. 2003;301:1545-1547.: Transport of dsRNA into cells by the transmembrane protein SID-1. PUBMED:12970568 EPMC:12970568 .
Winston WM, Molodowitch C, Hunter CP;, Science. 2002;295:2456-2459.: Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1. PUBMED:11834782 EPMC:11834782 .
Dong Y, Friedrich M;, BMC Biotechnol. 2005;5:25.: Nymphal RNAi: systemic RNAi mediated gene knockdown in juvenile grasshopper. PUBMED:16202143 EPMC:16202143 .
Pei J, Millay DP, Olson EN, Grishin NV;, Biol Direct. 2011;6:37.: CREST--a large and diverse superfamily of putative transmembrane hydrolases. PUBMED:21733186 EPMC:21733186.