EuRBPDB

Microtus_ochrogasterFamily: Sas10_Utp3 Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Utp3
C1d
Ngdn

Introduction

Pfam

This family contains Utp3 and LCP5 which are components of the U3 ribonucleoprotein complex [2]. It also includes the human C1D protein and Saccharomyces cerevisiae YHR081W (rrp47), an exosome-associated protein required for the 3' processing of stable RNAs [3] and Sas10 which has been identified as a regulator of chromatin silencing [1]. This family also includes the human protein Neuroguidin an initiation factor 4E (eIF4E) binding protein [6].

InterPro

This family contains Utp3 and LCP5 which are components of the U3 ribonucleoprotein complex [PUBMED:12068309]. It also includes the Homo sapiens (Human) C1D protein and Saccharomyces cerevisiae (Baker's yeast) YHR081W (rrp47), an exosome-associated protein required for the 3' processing of stable RNAs [PUBMED:9611201] and Sas10 which has been identified as a regulator of chromatin silencing [PUBMED:12972615]. This entry also includes the human protein Neuroguidin, an initiation factor 4E (eIF4E)-binding protein [PUBMED:9611201].

Reference

  1. Kamakaka RT, Rine J; , Genetics 1998;149:903-914.: Sir- and silencer-independent disruption of silencing in Saccharomyces by Sas10p. PUBMED:9611201 EPMC:9611201 .

  2. Dragon F, Gallagher JE, Compagnone-Post PA, Mitchell BM, Porwancher KA, Wehner KA, Wormsley S, Settlage RE, Shabanowitz J, Osheim Y, Beyer AL, Hunt DF, Baserga SJ; , Nature 2002;0:0-0.: A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. PUBMED:12068309 EPMC:12068309 .

  3. Mitchell P, Petfalski E, Houalla R, Podtelejnikov A, Mann M, Tollervey D; , Mol Cell Biol 2003;23:6982-6992.: Rrp47p is an exosome-associated protein required for the 3' processing of stable RNAs. PUBMED:12972615 EPMC:12972615 .

  4. Venema J, Tollervey D; , Annu Rev Genet 1999;33:261-311.: Ribosome synthesis in Saccharomyces cerevisiae. PUBMED:10690410 EPMC:10690410 .

  5. Wiederkehr T, Pretot RF, Minvielle-Sebastia L; , RNA. 1998;4:1357-1372.: Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation. PUBMED:9814757 EPMC:9814757 .

  6. Jung MY, Lorenz L, Richter JD; , Mol Cell Biol. 2006;26:4277-4287.: Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein. PUBMED:16705177 EPMC:16705177.