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The highly conserved and essential protein Ssu72 has intrinsic phosphatase activity and plays an essential role in the transcription cycle. Ssu72 was originally identified in a yeast genetic screen as enhancer of a defect caused by a mutation in the transcription initiation factor TFIIB . It binds to TFIIB and is also involved in mRNA elongation. Ssu72 is further involved in both poly(A) dependent and independent termination. It is a subunit of the yeast cleavage and polyadenylation factor (CPF), which is part of the machinery for mRNA 3'-end formation. Ssu72 is also essential for transcription termination of snRNAs .
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Sun ZW, Hampsey M; , Mol Cell Biol 1996;16:1557-1566.: Synthetic enhancement of a TFIIB defect by a mutation in SSU72, an essential yeast gene encoding a novel protein that affects transcription start site selection in vivo. PUBMED:8657130 EPMC:8657130 .
Dichtl B, Blank D, Ohnacker M, Friedlein A, Roeder D, Langen H, Keller W; , Mol Cell 2002;10:1139-1150.: A role for SSU72 in balancing RNA polymerase II transcription elongation and termination. PUBMED:12453421 EPMC:12453421 .
Ganem C, Devaux F, Torchet C, Jacq C, Quevillon-Cheruel S, Labesse G, Facca C, Faye G; , EMBO J 2003;22:1588-1598.: Ssu72 is a phosphatase essential for transcription termination of snoRNAs and specific mRNAs in yeast. PUBMED:12660165 EPMC:12660165.