EuRBPDB

Mus_caroliFamily: Ssu72 Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Ssu72

Introduction

Pfam

The highly conserved and essential protein Ssu72 has intrinsic phosphatase activity and plays an essential role in the transcription cycle. Ssu72 was originally identified in a yeast genetic screen as enhancer of a defect caused by a mutation in the transcription initiation factor TFIIB [1]. It binds to TFIIB and is also involved in mRNA elongation. Ssu72 is further involved in both poly(A) dependent and independent termination. It is a subunit of the yeast cleavage and polyadenylation factor (CPF), which is part of the machinery for mRNA 3'-end formation. Ssu72 is also essential for transcription termination of snRNAs [4].

InterPro

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Reference

  1. Sun ZW, Hampsey M; , Mol Cell Biol 1996;16:1557-1566.: Synthetic enhancement of a TFIIB defect by a mutation in SSU72, an essential yeast gene encoding a novel protein that affects transcription start site selection in vivo. PUBMED:8657130 EPMC:8657130 .

  2. Dichtl B, Blank D, Ohnacker M, Friedlein A, Roeder D, Langen H, Keller W; , Mol Cell 2002;10:1139-1150.: A role for SSU72 in balancing RNA polymerase II transcription elongation and termination. PUBMED:12453421 EPMC:12453421 .

  3. St-Pierre B, Liu X, Kha LC, Zhu X, Ryan O, Jiang Z, Zacksenhaus E; , Nucleic Acids Res 2005;33:464-477.: Conserved and specific functions of mammalian ssu72. PUBMED:15659578 EPMC:15659578 .

  4. Meinhart A, Kamenski T, Hoeppner S, Baumli S, Cramer P; , Genes Dev 2005;19:1401-1415.: A structural perspective of CTD function. PUBMED:15964991 EPMC:15964991 .

  5. Ganem C, Devaux F, Torchet C, Jacq C, Quevillon-Cheruel S, Labesse G, Facca C, Faye G; , EMBO J 2003;22:1588-1598.: Ssu72 is a phosphatase essential for transcription termination of snoRNAs and specific mRNAs in yeast. PUBMED:12660165 EPMC:12660165.