EuRBPDB

Microtus_ochrogasterFamily: TAP_C Number of Genes: 3

Ensembl ID	Symbol	Entrez ID
ENSMOCG00000000939	Nxf1	101998970
ENSMOCG00000010046	Nxf3	101994662
ENSMOCG00000016364	Nxf2	101994989

Introduction

Pfam

The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling [1]. The structure of the C-terminal domain is composed of four helices [1]. The structure is related to the UBA domain.

InterPro

The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling [PUBMED:11875519]. The structure of the C-terminal domain is composed of four helices [PUBMED:11875519]. The structure is related to the UBA domain.

Reference

Grant RP, Hurt E, Neuhaus D, Stewart M; , Nat Struct Biol 2002;9:247-251.: Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1. PUBMED:11875519 EPMC:11875519.