Saccharomyces_cerevisiaeFamily: THP2 Number of Genes: 1
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The THO complex plays a role in coupling transcription elongation to mRNA export. It is composed of subunits THP2, HPR1, THO2 and MFT1 [1].


Thp2 is part of the THO complex (Thp2, Hpr1, Tho2 and Mft1). The THO complex is the central component of the TREX complex, which is a key player in the transport of mRNA from the nucleus to the cytoplasm [PUBMED:11060033]. The THO complex plays a role in transcription elongation [PUBMED:15901496].


  1. Chavez S, Beilharz T, Rondon AG, Erdjument-Bromage H, Tempst P, Svejstrup JQ, Lithgow T, Aguilera A; , EMBO J. 2000;19:5824-5834.: A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. PUBMED:11060033 EPMC:11060033 .

  2. Jimeno S, Rondon AG, Luna R, Aguilera A; , EMBO J. 2002;21:3526-3535.: The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. PUBMED:12093753 EPMC:12093753.