The THUMP domain is named after after thiouridine synthases, methylases and PSUSs . The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains . It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets .
The THUMP (after thiouridine synthases, RNA methylases and pseudouridine synthases) domain is a module of 100-110 amino acid residues which is involved RNA metabolism. It is shared by enzymes that are predicted to carry out at least three unrelated types of RNA-modification, namely methylation, pseudouridylation and thiouridylation. The THUMP domain can occur in stand- alone form or in association with a variety of catalytic domains, like methylase, pseudo U-synthase or rhodanese. THUMP is an ancient domain with predicted RNA-binding capacity that probably functions by delivering a variety of RNA modification enzymes to their targets. The THUMP domain apparently evolved prior to the divergence of the primary divisions of life [PUBMED:11295541].
Aravind L, Koonin EV; , Trends Biochem Sci 2001;26:215-217.: THUMP - a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases. PUBMED:11295541 EPMC:11295541 .
Waterman DG, Ortiz-Lombardia M, Fogg MJ, Koonin EV, Antson AA; , J Mol Biol. 2006;356:97-110.: Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domain. PUBMED:16343540 EPMC:16343540.