EuRBPDB

Haplochromis_burtoniFamily: TRM13 Number of Genes: 1

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
ENSHBUG00000007754	trmt13	102299874

Introduction

Pfam

This is a family of eukaryotic proteins which are responsible for 2'-O-methylation of tRNA at position 4 [1]. TRM13 shows no sequence similarity to other known methyltransferases.

InterPro

This entry consists of eukaryotic and bacterial proteins that specifically methylates guanosine-4 in various tRNAs with a Gly(CCG), His or Pro signatures [PUBMED:17242307]. The alignment contains some conserved cysteines and histidines that might form a zinc binding site.

Reference

Wilkinson ML, Crary SM, Jackman JE, Grayhack EJ, Phizicky EM; , RNA. 2007; [Epub ahead of print]: The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4. PUBMED:17242307 EPMC:17242307.