Mus_musculus_c3hhejFamily: Tap-RNA_bind Number of Genes: 4
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Nxf1
-
Nxf2
-
Nxf7
-
Nxf3
-

Introduction

Pfam

Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element [1].

InterPro

This domain adopts a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. It is mainly found in mRNA export factors, which mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element [PUBMED:11854490].

Reference

  1. Ho DN, Coburn GA, Kang Y, Cullen BR, Georgiadis MM; , Proc Natl Acad Sci U S A. 2002;99:1888-1893.: The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor. PUBMED:11854490 EPMC:11854490.