EuRBPDB

Haplochromis_burtoniFamily: Tho2 Number of Genes: 1

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
ENSHBUG00000003516	thoc2	102304442

Introduction

Pfam

THO and TREX form a eukaryotic complex which functions in messenger ribonucleoprotein metabolism and plays a role in preventing the transcription-associated genetic instability [1,2]. Tho2, along with four other subunits forms THO [2]

InterPro

THO and TREX form a eukaryotic complex which functions in messenger ribonucleoprotein metabolism and plays a role in preventing the transcription-associated genetic instability [PUBMED:16581804],[PUBMED:17960421]. Tho2, along with four other subunits forms THO [PUBMED:17960421].

Reference

Wellinger RE, Prado F, Aguilera A; , Mol Cell Biol. 2006;26:3327-3334.: Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex. PUBMED:16581804 EPMC:16581804 .
Garcia-Rubio M, Chavez S, Huertas P, Tous C, Jimeno S, Luna R, Aguilera A; , Mol Genet Genomics. 2008;279:123-132.: Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity. PUBMED:17960421 EPMC:17960421 .
Chavez S, Beilharz T, Rondon AG, Erdjument-Bromage H, Tempst P, Svejstrup JQ, Lithgow T, Aguilera A; , EMBO J. 2000;19:5824-5834.: A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. PUBMED:11060033 EPMC:11060033.