EuRBPDB

Anabas_testudineusFamily: Tudor-knot Number of Genes: 7

Ensembl ID	Symbol	Entrez ID
ENSATEG00000002120	MSL3	113164046
ENSATEG00000009987	morf4l1	113165842
ENSATEG00000014386	arid4a	113147903
ENSATEG00000014930	tomm20a	113158387
ENSATEG00000016047	kat5b	113170421
ENSATEG00000018759	-	113174836
ENSATEG00000019285	kat8	113158851

Introduction

Pfam

This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilisation of Ht2 is essential for RNA binding [1].

InterPro

This is a novel knotted tudor domain which is required for binding to RNA. The knot influences the loop conformation of the helical turn Ht2 (residues 61-63) that is located at the side opposite the knot in the tudor domain-chromo domain; stabilisation of Ht2 is essential for RNA binding [PUBMED:18407291].

Reference

Shimojo H, Sano N, Moriwaki Y, Okuda M, Horikoshi M, Nishimura Y; , J Mol Biol. 2008;378:987-1001.: Novel structural and functional mode of a knot essential for RNA binding activity of the Esa1 presumed chromodomain. PUBMED:18407291 EPMC:18407291.