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No Pfam abstract.
This entry represents PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain containing proteins such as the ribosomal biogenesis factor NIP7 [PUBMED:9271378, PUBMED:9891085]. PUA domains are predicted to bind RNA molecules with complex folded structures [PUBMED:10093218]. NIP7 is required for efficient 60S ribosome subunit biogenesis and has been shown to interact with another essential nucleolar protein, Nop8p, and the exosome subunit Rrp43p. These three proteins are required for 60S subunit synthesis and may be part of a dynamic complex involved in this process.
Liu JF, Wang XQ, Wang ZX, Chen JR, Jiang T, An XM, Chang WR, Liang DC;, J Struct Biol. 2004;148:370-374.: Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells. PUBMED:15522784 EPMC:15522784.