| Ensembl ID | Symbol | Entrez ID | RBD | RBPome | PRI | Expresion | Pathway | Phenotype | Paralog | Ortholog | GO |
|---|---|---|---|---|---|---|---|---|---|---|---|
Urm1 is a ubiquitin related protein that modifies proteins in the yeast ubiquitin-like pathway urmylation [1]. Structural comparisons and phylogenetic analysis of the ubiquitin superfamily has indicated that Urm1 has the most conserved structural and sequence features of the common ancestor of the entire superfamily [2].
Ubiquitin related modifier 1 (Urm1) is a ubiquitin related protein that modifies proteins in the yeast ubiquitin-like urmylation pathway [PUBMED:16864801]. Structural comparisons and phylogenetic analysis of the ubiquitin superfamily has indicated that Urm1 has the most conserved structural and sequence features of the common ancestor of the entire superfamily [PUBMED:14551258]. Urm1 acts as a sulfur carrier required for 2-thiolation of mcm5S2U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) [PUBMED:21209336].
Xu J, Zhang J, Wang L, Zhou J, Huang H, Wu J, Zhong Y, Shi Y; , Proc Natl Acad Sci U S A. 2006;103:11625-11630.: Solution structure of Urm1 and its implications for the origin of protein modifiers. PUBMED:16864801 EPMC:16864801 .
Goehring AS, Rivers DM, Sprague GF Jr; , Mol Biol Cell. 2003;14:4329-4341.: Urmylation: a ubiquitin-like pathway that functions during invasive growth and budding in yeast. PUBMED:14551258 EPMC:14551258.
