EuRBPDB

Mus_musculus_c3hhejFamily: W2 Number of Genes: 7
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Bzw1
-
Bzw2
-
Eif5
-
Eif2b5
-
Eif4g1
-
Eif4g3
-
Eif4g2
-

Introduction

Pfam

This domain of unknown function is found at the C-terminus of several translation initiation factors [1].

InterPro

Translation initiation is a sophisticated, well regulated and highly coordinated cellular process in eukaryotes, in which at least 11 eukayrotic initiation factors (eIFs) are included. The W2 domain (two invariant tryptophans) is a region of ~165 amino acids which is found in the C terminus of the following eIFs [PUBMED:8520487, PUBMED:10958635, PUBMED:14681227, PUBMED:16616930, PUBMED:16781736]:

Reference

  1. Koonin EV; , Protein Sci 1995;4:1608-1617.: Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifs. PUBMED:8520487 EPMC:8520487.