Mus_musculusFamily: XendoU Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



This is a family of endoribonucleases involved in RNA biosynthesis which has been named XendoU in Xenopus laevis. XendoU is a U-specific metal dependent enzyme that produces products with a 2'-3' cyclic phosphate termini.


This entry represents the EndoU endoribonucleases mostly from eukaryotes. The founding member XendoU is a uridylate-specific, divalent cation-dependent enzyme that produces molecules with 2',3'-cyclic phosphate ends [PUBMED:15755742, PUBMED:16895992]. The human Endou, known as PP11, has endoribonuclease activity with placental tissue specificity [PUBMED:18936097, PUBMED:28610924].


  1. Renzi F, Caffarelli E, Laneve P, Bozzoni I, Brunori M, Vallone B; , Proc Natl Acad Sci U S A. 2006;103:12365-12370.: The structure of the endoribonuclease XendoU: From small nucleolar RNA processing to severe acute respiratory syndrome coronavirus replication. PUBMED:16895992 EPMC:16895992.