EuRBPDB

Anabas_testudineusFamily: eIF-3_zeta Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
eif3d

Introduction

Pfam

This family is made up of eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta/eIF3 p66/eIF3d). Eukaryotic initiation factor 3 is a multi-subunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilisation of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits. These functions and the complex nature of eIF3 suggest multiple interactions with many components of the translational machinery [1]. The gene coding for the protein has been implicated in cancer in mammals [2].

InterPro

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Reference

  1. Burks EA, Bezerra PP, Le H, Gallie DR, Browning KS; , J Biol Chem 2001;276:2122-2131.: Plant initiation factor 3 subunit composition resembles mammalian initiation factor 3 and has a novel subunit. PUBMED:11042177 EPMC:11042177 .

  2. Saramaki O, Willi N, Bratt O, Gasser TC, Koivisto P, Nupponen NN, Bubendorf L, Visakorpi T; , Am J Pathol 2001;159:2089-2094.: Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer. PUBMED:11733359 EPMC:11733359 .

  3. Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski K;, Nucleic Acids Res. 2012;40:7016-7045.: Sequence, structure and functional diversity of PD-(D/E)XK phosphodiesterase superfamily. PUBMED:22638584 EPMC:22638584.