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The largest of the mammalian translation initiation factors, eIF3, consists of at least eight subunits ranging in mass from 35 to 170 kDa. eIF3 binds to the 40 S ribosome in an early step of translation initiation and promotes the binding of methionyl-tRNAi and mRNA .
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Asano K, Kinzy TG, Merrick WC, Hershey JW; , J Biol Chem 1997;272:1101-1109.: Conservation and diversity of eukaryotic translation initiation factor eIF3. PUBMED:8995409 EPMC:8995409 .
Valasek L, Nielsen KH, Hinnebusch AG; , EMBO J 2002;21:5886-5898.: Direct eIF2-eIF3 contact in the multifactor complex is important for translation initiation in vivo. PUBMED:12411506 EPMC:12411506.