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Members of this family, which are found in the initiation factors eIF2 and EF-Tu, adopt a structure consisting of a beta barrel with Greek key topology. They are required for formation of the ternary complex with GTP and initiator tRNA .
This entry represents the C-terminal domain of the gamma subunit of eukaryotic translation initiation factor 2 (eIF2-gamma) found in Eukaryota and Archaea. eIF2 is a G protein that delivers the methionyl initiator tRNA to the small ribosomal subunit and releases it upon GTP hydrolysis after the recognition of the initiation codon. eIF2 is composed three subunits, alpha, beta and gamma. Subunit gamma shows strongest conservation, and it confers both tRNA binding and GTP/GDP binding [PUBMED:11927566, PUBMED:23291527].
Schmitt E, Blanquet S, Mechulam Y; , EMBO J. 2002;21:1821-1832.: The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors. PUBMED:11927566 EPMC:11927566.