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This domain family is found in eukaryotes, and is approximately 130 amino acids in length. The family is found in association with PF00076. This family is subunit G of the eukaryotic translation initiation factor 3. Subunit G is required for eIF3 integrity.
At least eleven different protein factors are involved in initiation of protein synthesis in eukaryotes. Binding of initiator tRNA and mRNA to the 40S subunit requires the presence of the translation initiation factors eIF-2 and eIF-3, with eIF-3 being particularly important for 80S ribosome dissociation and mRNA binding [PUBMED:1742346]. eIF-3 is the most complex translation inititation factor, consisting of about 13 putative subunits and having a molecular weight of between 550 - 700 kDa in mammalian cells. Subunits are designated eIF-3a - eIF-3m; the large number of subunits means that the interactions between the individual subunits that make up the eIF-3 complex are complex and varied.
Masutani M, Sonenberg N, Yokoyama S, Imataka H;, EMBO J. 2007;26:3373-3383.: Reconstitution reveals the functional core of mammalian eIF3. PUBMED:17581632 EPMC:17581632.