EuRBPDB

Haplochromis_burtoniFamily: mRNA_cap_enzyme Number of Genes: 2

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
ENSHBUG00000006950	snupn	102310782
ENSHBUG00000023823	rngtt	102301863

Introduction

Pfam

This family represents the ATP binding catalytic domain of the mRNA capping enzyme.

InterPro

This entry represents the ATP binding catalytic domain of the mRNA capping enzyme [PUBMED:9160746]. The mRNA capping enzyme in yeasts is composed of two separate chains, alpha a mRNA guanyltransferase and beta an RNA 5'-triphosphate. X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes [PUBMED:9160746]. Binding of the enzyme to nucleotides is specific to the GMP moiety of GTP. The viral mRNA capping enzyme is a monomer that transfers a GMP cap onto the end of mRNA that terminates with a 5'-diphosphate tail.

Reference

Hakansson K, Doherty AJ, Shuman S, Wigley DB; , Cell 1997;89:545-553.: X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes. PUBMED:9160746 EPMC:9160746.