EuRBPDB

Mus_musculus_c3hhejFamily: rRNA_proc-arch Number of Genes: 2

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
MGP_C3HHeJ_G0020680	Skiv2l2	-
MGP_C3HHeJ_G0023318	Skiv2l	-

Introduction

Pfam

Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homologue of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity [1].

InterPro

The essential RNA helicase Mtr4 is an exosome-activating cofactor. This arch domain can be found in Mtr4 and Ski2 (the cytosolic homologue of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity [PUBMED:20512111].

Reference

Jackson RN, Klauer AA, Hintze BJ, Robinson H, van Hoof A, Johnson SJ;, EMBO J. 2010;29:2205-2216.: The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing. PUBMED:20512111 EPMC:20512111.